Abstract

Several studies were done on the benefits of salmon peptide extract to improve joint health by repairing damaged cartilage, reduce osteoarthritis and assist in calcium absorption for bone health. This article will review the effects of salmon peptides extract against bone and joint health obtained from online literature searches.

Introduction

The interests of salmon peptides or hydrolysates as nutraceutical food have grown in the last years. The term ‘nutraceutical’ was coined by DeFelice (1) to describe “any substance that is a food or part of a food and provides medical or health benefits, including the prevention and treatment of disease”. This review article will highlight the findings of previous studies on the effects of salmon peptides extract on the bone and joint health of mammals.

Function (Anti-hypertension, lowering cholesterol and triglycerides)

Salmon Peptides in the form of hydrolyzed collagen in dietary supplementation have been verified to involve in the synthesis of extracellular matrix for improving the joint (2).

In addition, fish collagen peptides, when orally administrated, can repair damaged cartilage and can have synergistic effects with N-acetyl glucosamine (3).

Colllagen hydrolysates also have beneficial effect to patient with osteoarthritis (3).

Studies on fish peptides have demonstrated their capability of accelerating calcium absorption (4).

Although the beneficial effect of collagen hydrolysates on joint pain is known from the Middle Age, scientific evidences on the effective management of osteoarthritis with collagen hydrolysates have recently been reported (2) (4) (6).

In human, clinical studies with patients suffering joint disease, gelatine hydrolysates seemed to exert a direct effect on cartilage (2).

These gelatine peptides would accumulate preferably in cartilage, where they finally may stimulate cartilage metabolism (6).

Some evidence exist on the ability of collagen hydrolysates to stimulate biosynthesis of type II collagen and proteoglycans in chondrocytes (7).

aabe et al. (8) have reported the marked effect of a fish collagen hydrolysate on chondrogenic differentiation of equine adipose tissue-derived stromal cells.

In addition, oral administration of collagen hydrolysates would provide high levels of Gly and Pro, two amino acids essentials for the stability and regeneration of cartilage (9).

Animal models study also found that hydrolyzed collagen-enriched diet may improve bone collagen metabolism and bone mineral density in rats and mice which had a calcium- or protein-deficient diet (10) (11).

The mechanism by which oral administration of hydrolyzed collagen may improve bone formation in rats remain unclear, but has been suspected to be associated with the release and absorption of collagen derived peptides acting on bone metabolism, as observed in cartilage (6).

Conclusion

The consumption of salmon peptide extracts such as collagen peptide holds a potential to enhance the bone and joint health in animals.

References

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