Abstract

Roses are best known as ornamental plants grown for their attractive or scented foliage. Besides possessing perfuming effect, it also possesses useful rose placenta extract, which can affect the central nervous system function such as being antihypnotic, anticonvulsant, stress adjustment, mental relaxation and also improve the cognition function and memory. This article will review the effects of rose placenta extract. Online literature searches were performed to identify the studies about the Rosaceae family flowers especially Rosa damascena spesies.

Introduction

The Rose Placenta Extract is derived from Rosaceae family flowers where the most commonly used is the species Rosa damascene. Historical records show roses were planted and consumed for medical purposes by the ancient Chinese and Egyptians nearly 5,000 years ago, as well as in ancient Greece and the Roman Empire (1).

Various products and constit­uents isolated from the flowers, petals, and hips of this plant have been studied in vivo and in vitro, and have been shown to have antihypnotic, anticonvulsive, anti-Human immunodefi­ciency Virus, antidiabetic, antibacterial, and anti-inflammatory effects (2). This review article will highlight the findings of previous studies on the effects of the Rosa damascena against the central nervous system.

The effects of R. damascena against the central nervous system

The consumption of Rosa damascena had shown that it contributes to stress adjustment, relaxation and suppression of hypothalamus-pituitary activity (3) (4) (5).

Previous study also revealed that R. demascena  has some effects on central nervous system including hypnotic, anticonvulsant, anti-depressant, antianxiety, analgesic, and neuroprotective effects (5)(6)(7)(8)(9)(10)(11) .

It has been previously suggested that the flavonoids compound present in R. damascene has acted as anticonvulsant and antioxidant that may have interaction with GABAergic system in the brain (8) (12)(13)(14). These findings had been supported when flavonoids were successfully isolated from R.damascena by other previous study (18).

The flavonoids from plant based source have been studied in animal dietary supplementation and result shown that the cognition function has improved suggesting due to its protective effect on vulnerable neurons, enhancing existing neuronal function or by stimulating neuronal regeneration (15).

In addition, flavonoids may also participate in the beneficial effects on memory and preventing cognitive losses that caused by ageing and reversing certain age-related declines (16) (17).

Conclusion

The extract yielded from rose placenta as having beneficial compound such as flavonoids is contributive to the healthiness of central nervous system particularly for the intelligence, behavior and well-being of pets when fed as a dietary supplement.

References

1. Slavov A, Kiyohara H, Yamada H. Immunomodulating pec­tic polysaccharides from waste rose petals of Rosa damasce­na Mill. Int J Biol Macromol 2013;59:192-200
2. Bani S, Hasanpour S, Mousavi Z, et al. The effect of rosa damascena extract on primary dysmenorrhea: a double-blind cross-over clinical trial. Iran Red Crescent Med J 2014;16: e14643.
3. Zargari A. 1992. Medicinal plants, vol. 2, Tehran University Press, Tehran.
4. Ernst E, Barnes J, Abbot NC, Armstrong NC, Harkness E, Pittler MH, Stevinson C, Vogler B, White AR. 1998. The Di Bella story: emotion as opposed to fact. Focus Alternative Compl Ther, 3: 143-143.
5. Rakhshandah H, Hosseini M. 2006. Potentiation of pentobarbital hypnosis by Rosa damascena in mice. Indian J Exp Biol, 44: 910-912.
6. Mahmood N, Piacente S, Pizza C, Burke A, Khan AI, Hay AJ. 1996. The Anti-HIV Activity and Mechanisms of Action of Pure Compounds Isolated from Rosa damascena. Biochem Biophys Res Commun, 229: 73-79.
7. Nyeem M, Alam M, Awal M, Mostofa M, Uddin S, Islam N, ROUF R. 2007. CNS depressant effect of the crude ethanolic extract of the flowering tops of Rosa Damascena. Iran J Pharm Therap, 5:171-174.
8. Kheirabadi M, Moghimi A, Rakhshande H, Rassouli MB. 2008. Evaluation of the anticonvulsant activities of Rosa damascena on the PTZ induced seizures in wistar rats. J Biol Sci, 8: 426-430.
9. Hajhashemi V, Ghannadi A, Hajiloo M. 2010. Analgesic and Anti-inflammatory Effects of Rosa damascena Hydroalcoholic Extract and its Essential Oil in Animal Models. Iran J Pharm Res, 9: 163-168.
10. Rakhshandah H, Boskabady M, Mousavi Z, Gholami maliheh SZ. 2010. The Differences in the relaxant effects of different fractions of Rosa damascena on guinea pig tracheal smooth muscle. Iran J Basic Med Sci, 13: 126-132
11. Boskabady MH, Shafei MN, Saberi Z, Amini S. 2011. Pharmacological effects of rosa damascena. Iran J Basic Med Sci, 14: 295-307.
12. Rakotonirina VS, Bum EN, Rakotonirina A, Bopelet M. 2001. Sedative properties of the decoction of the rhizome of Cyperus articulatus. Fitoterapia, 72: 22-29.
13. Hosseini M, Harandizadeh F, Niazamand S, Soukhtanloo M, Mahmoudabady M. 2013. Antioxidant effect of Achillea wilhelmsii extract on pentylenetetrazole (seizure model)-induced oxidative brain damage in Wistar rats. Indian J Physiol Pharmacol, 57:418-24.
14. Hosseini M, Harandizadeh F, Niazmand S, Soukhtanloo M, Faizpour A, Ghasem abady M. 2014. The role for nitric oxide on the effects of hydroalcoholic extract of Achillea wilhelmsii on seizure. Avicenna J Phytomed, 4: 251-259.
15. Youdim KA, Joseph JA (2001) A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radic Biol Med 30:583–594
16. Joseph JA, Shukitt-Hale B, Denisova NA et al (1999) Reversals of age-related declines in neuronal signal transduction, cognitive,
    and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19:8114–8121
17. Joseph JA, Shukitt-Hale B, Denisova NA et al (1998) Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 18:8047–805
18. Kumar N, Singh B, Kaul VK. Flavonoids from Rosa damascena Mill. Nat Prod Commun 2006; 1:623-626.