The Effects of Salmon Peptides Extract in Top Performance Product against the Bone and Joint Health of Mammals

By Dr. Marcel Gisain


Several studies were done on the benefits of salmon peptide extract to improve joint health by repairing damaged cartilage, reduce osteoarthritis and assist in calcium absorption for bone health. This article will review the effects of salmon peptides extract against bone and joint health obtained from online literature searches.


The interests of salmon peptides or hydrolysates as nutraceutical food have grown in the last years. The term ‘nutraceutical’ was coined by DeFelice (1) to describe “any substance that is a food or part of a food and provides medical or health benefits, including the prevention and treatment of disease”. This review article will highlight the findings of previous studies on the effects of salmon peptides extract on the bone and joint health of mammals.

Function (Anti-hypertension, lowering cholesterol and triglycerides)

Salmon Peptides in the form of hydrolyzed collagen in dietary supplementation have been verified to involve in the synthesis of extracellular matrix for improving the joint (2).

In addition, fish collagen peptides, when orally administrated, can repair damaged cartilage and can have synergistic effects with N-acetyl glucosamine (3).

Colllagen hydrolysates also have beneficial effect to patient with osteoarthritis (3).

Studies on fish peptides have demonstrated their capability of accelerating calcium absorption (4).

Although the beneficial effect of collagen hydrolysates on joint pain is known from the Middle Age, scientific evidences on the effective management of osteoarthritis with collagen hydrolysates have recently been reported (2) (4) (6).

In human, clinical studies with patients suffering joint disease, gelatine hydrolysates seemed to exert a direct effect on cartilage (2).

These gelatine peptides would accumulate preferably in cartilage, where they finally may stimulate cartilage metabolism (6).

Some evidence exist on the ability of collagen hydrolysates to stimulate biosynthesis of type II collagen and proteoglycans in chondrocytes (7).

aabe et al. (8) have reported the marked effect of a fish collagen hydrolysate on chondrogenic differentiation of equine adipose tissue-derived stromal cells.

In addition, oral administration of collagen hydrolysates would provide high levels of Gly and Pro, two amino acids essentials for the stability and regeneration of cartilage (9).

Animal models study also found that hydrolyzed collagen-enriched diet may improve bone collagen metabolism and bone mineral density in rats and mice which had a calcium- or protein-deficient diet (10) (11).

The mechanism by which oral administration of hydrolyzed collagen may improve bone formation in rats remain unclear, but has been suspected to be associated with the release and absorption of collagen derived peptides acting on bone metabolism, as observed in cartilage (6).


The consumption of salmon peptide extracts such as collagen peptide holds a potential to enhance the bone and joint health in animals.


  1. De Felice, S.L. The nutraceutical revolution: its impact on food industry R&D. Trends in Food Science & Technology, 1995, 6(2), 59-61.
  2. Moskowitz RW. 2000. Role of collagen hydrolysate in bone and joint disease. Semin ArithritisRheu 30:87–9.
  3. Savior, M. et al., Effect of cartilage regeneration by GlcNAc and fish collagen peptide, Chitin Chitosan Res 2006; 12:184.
  4. Bello, A. E, Collagen hydrolysate for the treatment of Osteoarthritis and other joint disorders: a review of literature, Current Medical Research Opinions 2006: Nov., 22 (11): 2221-32.
  5. Jung W-K, Park P-J, Byun H-G, Moon S-H, Kim S-K. Preparation of Hoki (Johnius belengerii) bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase. Food Chem 2005; 91:333–340.
  6. Oesser, S.; Adam, M.; Babel, W.; Seifert, J., Oral administration of (14)C labeled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Journal of Nutrition, 1999, 129(10), 1891-1895.
  7. Oesser, S.; Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Research, 2003, 311(3), 393-399.
  8. Raabe, O.; Reich, C.; Wenisch, S.; Hild, A.; Burg-Roderfeld, M.; Siebert, H.C.; Arnhold, S. Hydrolyzed fish collagen induced chondrogenic differentiation of equine adipose tissue-derived stromal cells. Histochemistry and Cell Biology, 2010, 134(6), 545-554.
  9. Walrand, S.; Chiotelli, E.; Noirt, F.; Mwewa, S.; Lassel, T. Consumption of a functional fermented milk containing collagen hydrolysate improves the concentration of collagen-specific amino acids in plasma. Journal of Agricultural and Food Chemistry, 2008, 56(17), 7790-7795.
  10. Koyama, Y.; Hirota, A.; Mori, H.; Takahara, H.; Kuwaba, K.; Kusubata, M.; Matsubara, Y.; Kasugai, S.; Itoh, M.; Irie, S. Ingestion of gelatine has differential effect on bone mineral density and body weight in protein undernutrition. Journal of Nutritional Science and Vitaminology, 2001, 47(1), 84- 86.
  11. Wu, J. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in
    growing and mature rats. Journal of bone and mineral metabolism, 2004, 22(6), 547-553.